Single molecule spectroscopy using photothermal tuning of optical microcavities

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	Single molecule spectroscopy using photothermal tuning of optical microcavities
其他题名	Single molecule spectroscopy using photothermal tuning of optical microcavities
	GOLDSMITH, RANDALL HOWARD; HEYLMAN, KEVIN DANIEL
	2017-01-03
专利权人	WISCONSIN ALUMNI RESEARCH FOUNDATION
公开日期	2017-01-03
授权国家	美国
专利类型	授权发明
摘要	A method comprises exposing the surface of an optical microcavity characterized by at least one resonance frequency to a sample such that a single particle or molecule from the sample adsorbs onto the surface of the microcavity; evanescently coupling a probe laser beam into the microcavity, the wavelength of the probe laser beam substantially matching the at least one resonance frequency; illuminating the surface of the microcavity with a free space pump light beam and moving the focal spot of the free space pump light beam such that the focal spot substantially overlaps with the single particle/molecule; and detecting light from the probe laser beam. The wavelength of the free space pump light beam generates sufficient heat via energy absorbed by the single particle/molecule to induce a shift in the at least one resonance frequency, thereby providing a change in an optical characteristic of the detected light.
其他摘要	一种方法包括将以至少一个共振频率为特征的光学微腔的表面暴露于样品，使得来自样品的单个颗粒或分子吸附到微腔的表面上;将探测激光束暂时耦合到所述微腔中，所述探测激光束的波长基本上匹配所述至少一个谐振频率;用自由空间泵浦光束照射所述微腔的表面，并移动所述自由空间泵浦光束的焦斑，使得所述焦斑基本上与所述单个粒子/分子重叠;以及检测来自所述探针激光束的光。自由空间泵浦光束的波长通过由单个粒子/分子吸收的能量产生足够的热量，以引起至少一个谐振频率的偏移，从而提供检测到的光的光学特性的变化。
授权日期	2017-01-03
申请日期	2015-02-13
专利号	US9535219
专利状态	授权
申请号	US14/621502
公开（公告）号	US9535219
IPC 分类号	G02B6/293 \| G01N21/77 \| G01N21/17 \| G02F1/01 \| H01S3/06
专利代理人	-
代理机构	BELL & MANNING, LLC
文献类型	专利
条目标识符	http://ir.opt.ac.cn/handle/181661/37800
专题	半导体激光器专利数据库
作者单位	WISCONSIN ALUMNI RESEARCH FOUNDATION
推荐引用方式 GB/T 7714	GOLDSMITH, RANDALL HOWARD,HEYLMAN, KEVIN DANIEL. Single molecule spectroscopy using photothermal tuning of optical microcavities. US9535219[P]. 2017-01-03.

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