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Medical ultrasound images are usually corrupted by the noise during their acquisition known as speckle. Speckle noise removal is a key stage in medical ultrasound image processing. Due to the ill-posed feature of image denoising, many regularization methods have been proved effective. This paper introduces an approach which collaborate both sparse dictionary learning and regularization method to remove the speckle noise. The method trains a redundant dictionary by an efficient dictionary learning algorithm, and then uses it in an image prior regularization model to obtain the recovered image. Experimental results demonstrate that the proposed model has enhanced performance both in despeckling and texture-preserving of medical ultrasound images compared to some popular methods. © COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.