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Optofluidic twin-core hollow fiber interferometer for label-free sensing of the streptavidin-biotin binding
Yang, Xinghua1; Yu, Wenting1; Liu, Zhihai1; Yang, Jun1; Zhang, Yu1; Kong, Depeng2; Long, Qunlong1; Yuan, Tingting1; Cao, Jiaming1; Yuan, Libo1,3; Oh, Kyunghwan4
作者部门信息光子学研究室
2018-12-20
发表期刊Sensors and Actuators, B: Chemical
ISSN09254005
卷号277页码:353-359
产权排序2
摘要

We proposed and experimentally demonstrated an optofluidic biosensor using a twin-core hollow optical fiber (TC-HOF) interferometer for label-free sensing of the streptavidin-biotin binding. The TC-HOF had a central hole and two cores were imbedded near its circumference. The central hole functioned as a microfluidic channel where the liquid was flown. One of the cores was suspended at the inner surface of the hole and served as sensing arm while the other core embedded in the cladding as the reference arm, which formed an integrated all-fiber Mach-Zehnder interferometer (MZI). Both ends of TC-HOF were serially spliced to multimode fiber-single mode fiber assembly, whose lateral positions were adjusted to maximize the interference visibility. Before the surface functionalization, the pristine TC-HOF MZI showed the RI sensitivity of 2577 nm/RIU. The suspended core's surface was chemically modified with streptavidin and biotin solutions were injected through micro-HOles in TC-HOF. Through the specific binding reaction between biotin and streptavidin, the effective refractive index (RI) around the sensing arm was modulated, which was detected by the spectral shifts in the interference patterns. The proposed sensor showed an excellent linear response to the biotin concentration in the range of 0.01–0.1 mg/mL and the net detection sensitivity of biotin was 16.9 nm/(mg/mL), which was achieved in a label-free manner. This device can be further applied to sensing and monitoring of the biochemical binding of biotin with various biomolecules such as cells, antigens, antibodies, and DNA in real-time and in situ. © 2018

DOI10.1016/j.snb.2018.09.032
收录类别SCI ; EI
语种英语
WOS记录号WOS:000453066700044
出版者Elsevier B.V.
EI入藏号20183805825578
引用统计
文献类型期刊论文
条目标识符http://ir.opt.ac.cn/handle/181661/30652
专题信息光子学研究室
通讯作者Yang, Xinghua
作者单位1.Key Laboratory of In-Fiber Integrated Optics, Ministry of Education, College of Science, Harbin Engineering University, Harbin; 150001, China;
2.State Key Laboratory of Transient Optics and Photonics, Xi'an Institute of Optics and Precision Mechanic, Chinese Academy of Sciences, Xi'an; 710119, China;
3.Photonics Research Center, Guilin University of Electronics Technology, Guilin; 541004, China;
4.Department of Physics, Yonsei University, Seoul; 03722, Korea, Republic of
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Yang, Xinghua,Yu, Wenting,Liu, Zhihai,et al. Optofluidic twin-core hollow fiber interferometer for label-free sensing of the streptavidin-biotin binding[J]. Sensors and Actuators, B: Chemical,2018,277:353-359.
APA Yang, Xinghua.,Yu, Wenting.,Liu, Zhihai.,Yang, Jun.,Zhang, Yu.,...&Oh, Kyunghwan.(2018).Optofluidic twin-core hollow fiber interferometer for label-free sensing of the streptavidin-biotin binding.Sensors and Actuators, B: Chemical,277,353-359.
MLA Yang, Xinghua,et al."Optofluidic twin-core hollow fiber interferometer for label-free sensing of the streptavidin-biotin binding".Sensors and Actuators, B: Chemical 277(2018):353-359.
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