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Aberration correction method based on double-helix point spread function
Wang, Zhaojun1,2; Cai, Yanan1,2; Liang, Yansheng1,2; Dan, Dan1,3; Yao, Baoli1,3; Lei, Ming1,3
Source PublicationJournal of Biomedical Optics
Contribution Rank1

Point spread function (PSF) engineering has met with lots of interest in various optical imaging techniques, including super-resolution microscopy, microparticle tracking, and extended depth-of-field microscopy. The intensity distributions of the modified PSFs often suffer from deteriorations caused by system aberrations, which greatly degrade the image contrast, resolution, or localization precision. We present an aberration correction method using a spiral-phase-based double-helix PSF as an aberration indicator, which is sensitive and quantitatively correlated to the spherical aberration, coma, and astigmatism. Superior to the routine iteration-based correction methods, the presented approach is iteration-free and the aberration coefficients can be directly calculated with the measured parameters, relieving the computing burden. The validity of the method is verified by both examining the intensity distribution of the conventional Gaussian PSF in three dimensions and observing muntjac skin fibroblast cells. This iteration-free correction method has a potential application in PSF engineering systems equipped with a spatial light modulator. ? 2018 Society of Photo-Optical Instrumentation Engineers (SPIE).

KeywordDaberration correction double-helix point spread function iteration-free
Indexed BySCI ; EI
WOS IDWOS:000463886200008
EI Accession Number20183805826511
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Document Type期刊论文
Corresponding AuthorLei, Ming
Affiliation1.Chinese Academy of Sciences, Xi'an Institute of Optics and Precision Mechanics, State Key Laboratory of Transient Optics and Photonics, No. 17 Xinxi Road, Xi'an, Shaanxi; 710119, China;
2.University of Chinese Academy of Sciences, No. 19 Yuquan Road, Shijingshan District Beijing; 100049, China;
3.Xi'an Jiaotong University, No. 28 Xianning West Road, Xi'an, Shaanxi; 710049, China
Recommended Citation
GB/T 7714
Wang, Zhaojun,Cai, Yanan,Liang, Yansheng,et al. Aberration correction method based on double-helix point spread function[J]. Journal of Biomedical Optics,2019,24(3).
APA Wang, Zhaojun,Cai, Yanan,Liang, Yansheng,Dan, Dan,Yao, Baoli,&Lei, Ming.(2019).Aberration correction method based on double-helix point spread function.Journal of Biomedical Optics,24(3).
MLA Wang, Zhaojun,et al."Aberration correction method based on double-helix point spread function".Journal of Biomedical Optics 24.3(2019).
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