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A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging
Cui, X. X.1; Fan, Q.1,2; Shi, S. J.3; Wen, W. H.4; Chen, D. F.5; Guo, H. T.1; Xu, Y. T.1; Gao, F.1; Nie, R. Z.1; Ford, Harold D.6; Tang, Gordon H.6; Hou, C. Q.1; Peng, B.1; Peng, B (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China.
作者部门先进光电与生物材料研发中心
2018-05-18
发表期刊NANOTECHNOLOGY
ISSN0957-4484
卷号29期号:20
产权排序1
摘要

Fluorescence imaging signal is severely limited by the quantum efficiency and emission wavelength. To overcome these challenges, novel NIR-emitting K5NdLi2F10 nanoparticles under NIR excitation was introduced as fluorescence imaging probe for the first time. The photostability of K5NdLi2F10 nanoparticles in the water, phosphate buffer saline, fetal bovine serum and living mice was investigated. The fluorescence signal was detected with depths of 3.5 and 2.0 cm in phantom and pork tissue, respectively. Fluorescence spectrum with a significant signal-to-background ratio of 10:1 was captured in living mice. Moreover, clear NIR images were virtualized for the living mice after intravenous injection. The imaging ability of nanoparticles in tumor-beard mice were evaluated, the enrichment of K5NdLi2F10 nanoparticles in tumor site due to the enhanced permeability and retention effect was confirmed. The systematic studies of toxicity, bio-distribution and in-vivo dynamic imaging suggest that these materials give high biocompatibility and low toxicity. These NIR-emitting nanoparticles with high quantum efficiency, high penetration and low toxicity might facilitate tumor identification in deep tissues more sensitively.

文章类型Article
关键词Nanomaterials Biomaterials Medical Optics And Biotechnology Fluorescence Microscopy Spectroscopy Fluorescence And Luminescence
学科领域Nanoscience & Nanotechnology
WOS标题词Science & Technology ; Technology ; Physical Sciences
DOI10.1088/1361-6528/aab2fa
收录类别SCI ; EI
关键词[WOS]2ND BIOLOGICAL WINDOW ; CARBON NANOTUBES ; LONG LIFETIME ; DOTS ; FLUORESCENCE ; NANOPARTICLES ; NANOCRYSTALS ; DIAGNOSTICS ; K5NDLI2F10
语种英语
WOS研究方向Science & Technology - Other Topics ; Materials Science ; Physics
项目资助者National Natural Science Foundation of China(61107015 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ8345) ; 61205039 ; 61475189)
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS记录号WOS:000428270900002
引用统计
文献类型期刊论文
条目标识符http://ir.opt.ac.cn/handle/181661/30021
专题先进光电与生物材料研发中心
通讯作者Peng, B (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China.
作者单位1.Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Fourth Millitary Med Univ, Xijing Hosp, Dept Urol, Xian 710032, Shaanxi, Peoples R China
4.Fourth Millitary Med Univ, Dept Immunol, State Key Lab Canc Biol, Xian 710069, Shaanxi, Peoples R China
5.Xi Dian Univ, Sch Life Sci & Biotechnol, Xian 710126, Shaanxi, Peoples R China
6.PTA Tech Inc, 315-515 West Pender St, Vancouver, BC V6B 6H5, Canada
推荐引用方式
GB/T 7714
Cui, X. X.,Fan, Q.,Shi, S. J.,et al. A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging[J]. NANOTECHNOLOGY,2018,29(20).
APA Cui, X. X..,Fan, Q..,Shi, S. J..,Wen, W. H..,Chen, D. F..,...&Peng, B .(2018).A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging.NANOTECHNOLOGY,29(20).
MLA Cui, X. X.,et al."A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging".NANOTECHNOLOGY 29.20(2018).
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