中国科学院西安光学精密机械研究所机构知识库
Advanced  
OPT OpenIR  > 先进光电与生物材料研发中心  > 期刊论文
题名:
A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging
作者: Cui, X. X.1; Fan, Q.1,2; Shi, S. J.3; Wen, W. H.4; Chen, D. F.5; Guo, H. T.1; Xu, Y. T.1; Gao, F.1; Nie, R. Z.1; Ford, Harold D.6; Tang, Gordon H.6; Hou, C. Q.1; Peng, B.1
作者部门: 先进光电与生物材料研发中心
刊名: NANOTECHNOLOGY
出版日期: 2018-05-18
卷号: 29, 期号:20
关键词: nanomaterials ; biomaterials ; medical optics and biotechnology ; fluorescence microscopy ; spectroscopy ; fluorescence and luminescence
学科分类: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
DOI: 10.1088/1361-6528/aab2fa
通讯作者: Peng, B (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China.
文章类型: Article
英文摘要:

Fluorescence imaging signal is severely limited by the quantum efficiency and emission wavelength. To overcome these challenges, novel NIR-emitting K5NdLi2F10 nanoparticles under NIR excitation was introduced as fluorescence imaging probe for the first time. The photostability of K5NdLi2F10 nanoparticles in the water, phosphate buffer saline, fetal bovine serum and living mice was investigated. The fluorescence signal was detected with depths of 3.5 and 2.0 cm in phantom and pork tissue, respectively. Fluorescence spectrum with a significant signal-to-background ratio of 10:1 was captured in living mice. Moreover, clear NIR images were virtualized for the living mice after intravenous injection. The imaging ability of nanoparticles in tumor-beard mice were evaluated, the enrichment of K5NdLi2F10 nanoparticles in tumor site due to the enhanced permeability and retention effect was confirmed. The systematic studies of toxicity, bio-distribution and in-vivo dynamic imaging suggest that these materials give high biocompatibility and low toxicity. These NIR-emitting nanoparticles with high quantum efficiency, high penetration and low toxicity might facilitate tumor identification in deep tissues more sensitively.

WOS标题词: Science & Technology ; Technology ; Physical Sciences
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: 2ND BIOLOGICAL WINDOW ; CARBON NANOTUBES ; LONG LIFETIME ; DOTS ; FLUORESCENCE ; NANOPARTICLES ; NANOCRYSTALS ; DIAGNOSTICS ; K5NDLI2F10
收录类别: SCI ; EI
项目资助者: National Natural Science Foundation of China(61107015 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ8345) ; 61205039 ; 61475189)
语种: 英语
WOS记录号: WOS:000428270900002
ISSN号: 0957-4484
产权排序: 1
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.opt.ac.cn/handle/181661/30021
Appears in Collections:先进光电与生物材料研发中心_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging.pdf(3337KB)期刊论文作者接受稿开放获取View 联系获取全文

作者单位: 1.Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Fourth Millitary Med Univ, Xijing Hosp, Dept Urol, Xian 710032, Shaanxi, Peoples R China
4.Fourth Millitary Med Univ, Dept Immunol, State Key Lab Canc Biol, Xian 710069, Shaanxi, Peoples R China
5.Xi Dian Univ, Sch Life Sci & Biotechnol, Xian 710126, Shaanxi, Peoples R China
6.PTA Tech Inc, 315-515 West Pender St, Vancouver, BC V6B 6H5, Canada

Recommended Citation:
Cui, X. X.,Fan, Q.,Shi, S. J.,et al. A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging[J]. NANOTECHNOLOGY,2018-05-18,29(20).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cui, X. X.]'s Articles
[Fan, Q.]'s Articles
[Shi, S. J.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cui, X. X.]‘s Articles
[Fan, Q.]‘s Articles
[Shi, S. J.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
文件名: A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Powered by CSpace