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A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging
Cui, X. X.1; Fan, Q.1,2; Shi, S. J.3; Wen, W. H.4; Chen, D. F.5; Guo, H. T.1; Xu, Y. T.1; Gao, F.1; Nie, R. Z.1; Ford, Harold D.6; Tang, Gordon H.6; Hou, C. Q.1; Peng, B.1; Peng, B (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China.
Department先进光电与生物材料研发中心
2018-05-18
Source PublicationNANOTECHNOLOGY
ISSN0957-4484
Volume29Issue:20
Contribution Rank1
Abstract

Fluorescence imaging signal is severely limited by the quantum efficiency and emission wavelength. To overcome these challenges, novel NIR-emitting K5NdLi2F10 nanoparticles under NIR excitation was introduced as fluorescence imaging probe for the first time. The photostability of K5NdLi2F10 nanoparticles in the water, phosphate buffer saline, fetal bovine serum and living mice was investigated. The fluorescence signal was detected with depths of 3.5 and 2.0 cm in phantom and pork tissue, respectively. Fluorescence spectrum with a significant signal-to-background ratio of 10:1 was captured in living mice. Moreover, clear NIR images were virtualized for the living mice after intravenous injection. The imaging ability of nanoparticles in tumor-beard mice were evaluated, the enrichment of K5NdLi2F10 nanoparticles in tumor site due to the enhanced permeability and retention effect was confirmed. The systematic studies of toxicity, bio-distribution and in-vivo dynamic imaging suggest that these materials give high biocompatibility and low toxicity. These NIR-emitting nanoparticles with high quantum efficiency, high penetration and low toxicity might facilitate tumor identification in deep tissues more sensitively.

SubtypeArticle
KeywordNanomaterials Biomaterials Medical Optics And Biotechnology Fluorescence Microscopy Spectroscopy Fluorescence And Luminescence
Subject AreaNanoscience & Nanotechnology
WOS HeadingsScience & Technology ; Technology ; Physical Sciences
DOI10.1088/1361-6528/aab2fa
Indexed BySCI ; EI
WOS Keyword2nd Biological Window ; Carbon Nanotubes ; Long Lifetime ; Dots ; Fluorescence ; Nanoparticles ; Nanocrystals ; Diagnostics ; K5ndli2f10
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Physics
Funding OrganizationNational Natural Science Foundation of China(61107015 ; Natural Science Basic Research Plan in Shaanxi Province of China(2014JQ8345) ; 61205039 ; 61475189)
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000428270900002
EI Accession Number20181404986398
Citation statistics
Document Type期刊论文
Identifierhttp://ir.opt.ac.cn/handle/181661/30021
Collection先进光电与生物材料研发中心
Corresponding AuthorPeng, B (reprint author), Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China.
Affiliation1.Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Fourth Millitary Med Univ, Xijing Hosp, Dept Urol, Xian 710032, Shaanxi, Peoples R China
4.Fourth Millitary Med Univ, Dept Immunol, State Key Lab Canc Biol, Xian 710069, Shaanxi, Peoples R China
5.Xi Dian Univ, Sch Life Sci & Biotechnol, Xian 710126, Shaanxi, Peoples R China
6.PTA Tech Inc, 315-515 West Pender St, Vancouver, BC V6B 6H5, Canada
Recommended Citation
GB/T 7714
Cui, X. X.,Fan, Q.,Shi, S. J.,et al. A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging[J]. NANOTECHNOLOGY,2018,29(20).
APA Cui, X. X..,Fan, Q..,Shi, S. J..,Wen, W. H..,Chen, D. F..,...&Peng, B .(2018).A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging.NANOTECHNOLOGY,29(20).
MLA Cui, X. X.,et al."A novel near-infrared nanomaterial with high quantum efficiency and its applications in real time in vivo imaging".NANOTECHNOLOGY 29.20(2018).
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