Tetherless Optical Neuromodulation Wavelength from Orange-red to Mid-infrared | |
Sun, Chao1,2; Fan, Qi1,2; Xie, Rougang3; Luo, Ceng3; Hu, Bingliang2; Wang, Quan1,2 | |
作者部门 | 光谱成像技术研究室 |
发表期刊 | NEUROSCIENCE BULLETIN |
ISSN | 1673-7067;1995-8218 |
产权排序 | 1 |
摘要 | Optogenetics, a technique that employs light for neuromodulation, has revolutionized the study of neural mechanisms and the treatment of neurological disorders due to its high spatiotemporal resolution and cell-type specificity. However, visible light, particularly blue and green light, commonly used in conventional optogenetics, has limited penetration in biological tissue. This limitation necessitates the implantation of optical fibers for light delivery, especially in deep brain regions, leading to tissue damage and experimental constraints. To overcome these challenges, the use of orange-red and infrared light with greater tissue penetration has emerged as a promising approach for tetherless optical neuromodulation. In this review, we provide an overview of the development and applications of tetherless optical neuromodulation methods with long wavelengths. We first discuss the exploration of orange-red wavelength-responsive rhodopsins and their performance in tetherless optical neuromodulation. Then, we summarize two novel tetherless neuromodulation methods using near-infrared light: upconversion nanoparticle-mediated optogenetics and photothermal neuromodulation. In addition, we discuss recent advances in mid-infrared optical neuromodulation. |
关键词 | Optical neuromodulation Tetherless Orange-red wavelength responding rhodopsins Upconversion nanoparticle-mediated optogenetics Photothermal neuromodulation |
DOI | 10.1007/s12264-024-01179-1 |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:001164917600002 |
出版者 | SPRINGER |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.opt.ac.cn/handle/181661/97249 |
专题 | 光谱成像技术研究室 |
通讯作者 | Wang, Quan |
作者单位 | 1.Chinese Acad Sci, Xian Inst Opt & Precis Mech XIOPM, Key Lab Spectral Imaging Technol, Xian 710119, Peoples R China 2.Chinese Acad Sci, Key Lab Biomed Spect Xian, Key Lab Spectral Imaging Technol, XIOPM, Xian 710119, Peoples R China 3.Fourth Mil Med Univ, Sch Basic Med, Dept Neurobiol, Xian 710032, Peoples R China |
推荐引用方式 GB/T 7714 | Sun, Chao,Fan, Qi,Xie, Rougang,et al. Tetherless Optical Neuromodulation Wavelength from Orange-red to Mid-infrared[J]. NEUROSCIENCE BULLETIN. |
APA | Sun, Chao,Fan, Qi,Xie, Rougang,Luo, Ceng,Hu, Bingliang,&Wang, Quan. |
MLA | Sun, Chao,et al."Tetherless Optical Neuromodulation Wavelength from Orange-red to Mid-infrared".NEUROSCIENCE BULLETIN |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Tetherless Optical N(1763KB) | 期刊论文 | 作者接受稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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