A novel photostable near-infrared-to-near-infrared fluorescent nanoparticle for in vivo imaging | |
Fan, Qi1,2; Cui, Xiaoxia1,3; Wang, Quan1; Gao, Peng4; Shi, Shengjia5; Wen, Weihua6; Guo, Haitao1,3; Xu, Yantao1,3; Peng, Bo1,3 | |
作者部门 | 先进光电与生物材料研究室 |
发表期刊 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS |
ISSN | 1552-4973;1552-4981 |
产权排序 | 1 |
摘要 | Water-soluble K5HoLi2F10 (KHLF) nanoprobes with the excitation and emission both in the near-infrared (NIR) region were developed and first demonstrated for in vivo imaging of living mice. The PEG(400) coating endows the nanoprobes with good water solubility and biocompatibility. Doping with Ho3+ ions is capable of emitting NIR fluorescence with two peaks centered, respectively, at 887 and 1,180 nm once excited by a 808 nm laser; meanwhile, it also possess good photothermal conversion performance. The KHLF matrix with specifically structure of large ion-distance and low photon energy imparts the nanoprobes low quenching effect and excellent photostability (fluorescence decrease <5% upon 120 min illumination of 808 nm continuous laser with a power density of 1 W/cm(2)). The nanoparticles (NPs) were tested for in vitro bioimaging with living mice. The results show the NPs have low biotoxicity, rapid metabolism, normal biodistribution, together with the photothermal imaging performance and a high-contrast fluorescence images (signal-to-background ratio of 14:1). The superior performances of these nanoprobes in vivo imaging of mice proclaim the great potential of this type of probe for high-contrast imaging and photothermal treatment in practical applications. |
关键词 | biocompatible in vivo imaging near-infrared photostability probe |
DOI | 10.1002/jbm.b.34622 |
收录类别 | SCI ; EI |
语种 | 英语 |
WOS记录号 | WOS:000531096800001 |
出版者 | WILEY |
EI入藏号 | 20202008646670 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.opt.ac.cn/handle/181661/93425 |
专题 | 光子功能材料与器件研究室 |
通讯作者 | Cui, Xiaoxia; Peng, Bo |
作者单位 | 1.Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Shaanxi, Peoples R China 2.Univ Chinese Acad Sci UCAS, Beijing, Peoples R China 3.Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing, Peoples R China 4.Xidian Univ, Sch Phys & Optoelect Engn, Xian, Peoples R China 5.Fourth Mil Med Univ, Xijing Hosp, Dept Urol, Xian, Shaanxi, Peoples R China 6.Fourth Mil Med Univ, Dept Immunol, State Key Lab Canc Biol, Xian, Shaanxi, Peoples R China |
推荐引用方式 GB/T 7714 | Fan, Qi,Cui, Xiaoxia,Wang, Quan,et al. A novel photostable near-infrared-to-near-infrared fluorescent nanoparticle for in vivo imaging[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS. |
APA | Fan, Qi.,Cui, Xiaoxia.,Wang, Quan.,Gao, Peng.,Shi, Shengjia.,...&Peng, Bo. |
MLA | Fan, Qi,et al."A novel photostable near-infrared-to-near-infrared fluorescent nanoparticle for in vivo imaging".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS |
条目包含的文件 | ||||||
文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
A novel photostable (10635KB) | 期刊论文 | 出版稿 | 限制开放 | CC BY-NC-SA | 请求全文 |
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