Direct injection high efficiency nebulizer for analytical spectrometry

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	Direct injection high efficiency nebulizer for analytical spectrometry
其他题名	Direct injection high efficiency nebulizer for analytical spectrometry
	MONTASER, AKBAR; MCLEAN, JOHN A.; KACSIR, JEROLD M.
	2000-12-26
专利权人	GEORGE WASHINGTON UNIVERSITY
公开日期	2000-12-26
授权国家	美国
专利类型	授权发明
摘要	A simple, relatively low-cost direct injection high efficiency nebulizer (DIHEN) is suitable for argon inductively coupled plasma (Ar ICP) spectrometry. The DIHEN may be operated at solution uptake rates of 1-100 mu L/min. Analytical performance indices for the DIHEN and fundamental characteristics of the aerosol produced are obtained using an ICP mass spectrometer (ICPMS) and a 2-dimensional phase Doppler particle analyzer (2D PDPA), respectively. Results are compared to those obtained with a conventional crossflow pneumatic nebulizer (PN), equipped with a Scott-type spray chamber. Droplet sizes and velocities produced with the DIHEN are smaller than those reported for the direct injection nebulizer (DIN). The DIHEN offers optimal sensitivity at low injector gas flow rates (approx. 0.25 L/min) and high RF power (approx. 5 kW). For the 17 elements tested, detection limits (ppt) and sensitivities achieved with the DIHEN (at 85 mu L/min) are similar to or better than those obtained on the same instrument using the PN (at 1 mL/min). However, because the primary aerosol is injected directly into the plasma, oxide-to-metal ion ratios (MO+/M+) are high as in the case of the DIN. The utility of the DIHEN for the analysis of small volume samples is demonstrated by microscale flow injection analysis ( mu FIA) of Cr bound to human lung DNA. Detection of Cr at the femtogram level is feasible.
其他摘要	一种简单，成本相对较低的直接喷射高效雾化器（DIHEN）适用于氩电感耦合等离子体（Ar ICP）光谱测定。 DIHEN可以在1-100μL/ min的溶液吸收速率下操作。 DIHEN的分析性能指标和产生的气溶胶的基本特征分别使用ICP质谱仪（ICPMS）和二维相位多普勒粒子分析仪（2D PDPA）获得。将结果与使用配备Scott型喷雾室的传统横流式气动雾化器（PN）获得的结果进行比较。 DIHEN产生的液滴尺寸和速度小于直接喷射雾化器（DIN）报告的尺寸和速度。 DIHEN在低喷射器气体流速（约0.25 L / min）和高RF功率（约5 kW）下提供最佳灵敏度。对于测试的17种元素，使用DIHEN（85μL/ min）获得的检测限（ppt）和灵敏度与使用PN（以1 mL / min）在相同仪器上获得的相似或更好。然而，因为初级气溶胶直接注入等离子体中，所以氧化物与金属离子的比率（MO + / M +）高，如DIN的情况。 DIHEN用于分析小体积样品的效用通过与人肺DNA结合的Cr的微量流动注射分析（μFIA）来证明。在飞克级别检测Cr是可行的。
申请日期	1998-04-08
专利号	US6166379
专利状态	失效
申请号	US09/057198
公开（公告）号	US6166379
IPC 分类号	G01N21/71 \| H01J49/04 \| H01J49/02 \| G01N21/73 \| H01J49/12 \| G01J3/10
专利代理人	-
代理机构	KNOBBE,MARTENS,OLSON & BEAR,LLP
文献类型	专利
条目标识符	http://ir.opt.ac.cn/handle/181661/34464
专题	半导体激光器专利数据库
作者单位	GEORGE WASHINGTON UNIVERSITY
推荐引用方式 GB/T 7714	MONTASER, AKBAR,MCLEAN, JOHN A.,KACSIR, JEROLD M.. Direct injection high efficiency nebulizer for analytical spectrometry. US6166379[P]. 2000-12-26.

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